Gene symbol / ID, Anslutning #: CALB1, 539930 John B. Davis, Stefan Rose-John, och Michaela Kress; En nyckelroll för gp130 uttrycks på perifera sensoriska

genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. CNTF-CNTFR- gp130 -LIFR complex Gene Set

home > human > gp130 gene knockdown | 1 product cited in the literature; 10 total from 3 suppliers Your Filters. product. gp130 siRNA (h) Santa Cruz Biotechnology The role of gp130/Stat3 in promoting the expression of these genes in OVCAR-8 cells was confirmed by silencing of gp130 (Supplementary Fig. S4A) and Stat3 (Supplementary Fig. S4B). Importantly, silencing of Stat3 also reduced gp130 expression, which is consistent with a previous study unveiling a STAT-binding element located in the gp130 promoter region ( 29 ). We assessed the influence of Correspondence the IL6R and the IL6ST/gp130 genes in the risk of cardiovascular (CV) disease in ´ Dr Miguel A. Gonzalez-Gay Department of Rheumatology RA. For this purpose, 1250 Spanish patients with RA were genotyped for the IL6R ´ de Valdecilla Hospital Universitario Marques rs2228145 and IL6ST/gp130 rs2228044 functional gene polymorphisms. Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome Forskningsoutput : Tidskriftsbidrag › Artikel i vetenskaplig tidskrift Översikt Gp130 is expressed in all organs examined.

Gp130 gene

gp130/IL6ST overexpression lysate was created in HEK293 Cells, CHO Cells and intended The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. 2014-09-30 27 antibodies to GP130 and validated for use in 8 applications (Immunohistochemistry, Western Blot, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, ELISA, … Because we demonstrated that gp130 is critical to induce M2 signature genes in macrophages, we next sought to determine whether gp130 expression itself is regulated during macrophage polarization. Interestingly, we found that gp130 expression is strongly up‐regulated in BMDMs upon M2 polarization by IL‐4, which was further enhanced by combined treatment with IL‐4 and IL‐10 (Fig. 4 D ). An association between the gp130(IL6ST) gene adenine(A)/thymine(T)(rs1900173) polymorphism in women and human fertility has been previously reported.

The role of gp130/Stat3 in promoting the expression of these genes in OVCAR-8 cells was confirmed by silencing of gp130 (Supplementary Fig. S4A) and Stat3 (Supplementary Fig. S4B). Importantly, silencing of Stat3 also reduced gp130 expression, which is consistent with a previous study unveiling a STAT-binding element located in the gp130 promoter region ( 29 ).

GP130 is the shared receptor for members of the IL6 family of cytokines. Members of this family have been shown to enhance the survival of migratory(E10.5) or postmigratory (E12.5) murine primordial germ cells (PGCs) in culture; however, it is uncertain what role these cytokines play during PGC development in vivo.

genetic polymorphism. MeSH-ID. D020641. omnämnd som: Polymorphism, Single Nucleotide. MeSH-kod. G05.365.795.598. Wolfram Language entity type.

Fig. S6. 2019-05-17 · If gp130 expression is lower than IL-6Rα expression, gp130 acts as a bottleneck for trans- and classic signalling, hence, trans-signalling cannot surpass classic signalling. In line with this hypothesis HepG2 cells, where trans-signalling is stronger than classic signalling, express eight times more gp130 than IL-6Rα (Fig. 2 d). home > human > gp130 gene knockdown | 1 product cited in the literature; 10 total from 3 suppliers Your Filters. product. gp130 siRNA (h) Santa Cruz Biotechnology The role of gp130/Stat3 in promoting the expression of these genes in OVCAR-8 cells was confirmed by silencing of gp130 (Supplementary Fig. S4A) and Stat3 (Supplementary Fig. S4B). Importantly, silencing of Stat3 also reduced gp130 expression, which is consistent with a previous study unveiling a STAT-binding element located in the gp130 promoter region ( 29 ).

gp130/IL6ST Gene IL6ST gene / cDNA is a protein-coding gene which located on 5q11.2. The IL6ST gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.218 organisms have orthologs with human gene IL6ST. Learn more about gp130/IL6ST gene information & reagent We found that gene therapy with AAV9-gp130 ACT, encoding a sustainably activated form of gp130, could improve heart regeneration effectively with cardiomyocyte proliferation after MI in adult mice. This study indicates that gp130 is an effective cardiomyocyte proliferative target to improve heart regeneration and, from a clinical perspective, a gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. The gp130 gene located on the long arm of chromosome 5 (q11) (Rodriguez et al., 1995), comprising 17 exons and 16 introns (Fig. 1). The sequences and the positions of the exon–intron boundaries, and the estimated length of the introns are summarized in Table 2.
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2013-06-01 National Center for Biotechnology Information Functional redundancy of the IL-6 cytokine family results from the use of the common receptor subunit gp130, 2 while the pleiotropic actions are associated with the coordinated and simultaneous activation of multiple signaling cascades which ultimately modulate gene expression and cellular responses. Ligand-induced gp130 homodimerization in response to IL-6 and IL-11, 9,10 or sIL-6ST/gp130/CD130 Human ELISA Kit from Invitrogen (96 Tests). Quantitate human GP130 in plasma, serum and supernatant. Sensitivity: 4 pg/mL gp130 Gene Set. From GeneRIF Biological Term Annotations. genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

- [Lund : Leukemia inhibitor factor (LIF) and gp130 in early Chromatin structure and histone modifications in gene regulation.
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Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function.

2014-09-30 2003-09-15 Upon gp130 activation, various APPs are produced within hepatocytes; in humans, mainly CRP and SAA, fibrinogen, haptoglobin, and angiotensinogen are produced. In mice, SAA represents the predominant APP, whereas CRP is a minor APP, potentially caused by the limited responsiveness of the gene to inflammatory cytokine signals (9). 2020-06-03 In order to obtain extensive inactivation of the gp130 gene, gp130 fl/fl;WC mice were taken through two pregnancies, followed by the analysis of mammary tissue during involution. In these mice involution and the associated tissue remodeling was greatly impaired ( Fig. 3B ), and the glands had a secretory appearance even 2 weeks after weaning ( Fig. 3C , panels b and d ). 2013-09-01 Similarly, exosome-mediated gp130/STAT3-induced gene expression was reduced when exosomes were pretreated with SC144 (Figure 4D). Finally, the morphological and pro-survival changes induced by cancer-derived exosomes in BMDMs were reverted by SC144-treated exosomes (Figures 4E,F). shRNA sequences correspond to gp130 siRNA Gene Silencer sequences; provided as transfection-ready purified plasmid DNA target-specific gene silencing; after transfection, cells stably expressing shRNAs can be isolated by puromycin selection; shRNA Plasmids are intended only for non-commercial use.

Status. Unreviewed - Annotation score: Annotation score:1 out of 5. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the …

gp130 genes, and this study therefore examined the hypothesis that LIFR and gp130 are RUNX1 target genes and their altered expression in leukemic cells in which RUNX1 is disrupted may therefore contribute to leukaemia. The LIFR gene is regulated by alternate promoters, with a so called ‘general’ and Glycoprotein 130 (also known as gp130, IL6ST or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. Functional redundancy of the IL-6 cytokine family results from the use of the common receptor subunit gp130, 2 while the pleiotropic actions are associated with the coordinated and simultaneous activation of multiple signaling cascades which ultimately modulate gene expression and cellular responses. Gene target CD130 gp130 Receptor Oncostatin M-R OSM-R IL-6 Signal Transducer Alternative to gene target oncostatin M, OSM and IDBG-4002 and ENSG00000099985 and 5008, growth factor activity, Extracellular, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, BT.45038 and IDBG-636338 and ENSBTAG00000016163 and 319086 genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Fig. S4. Xenograft growth is suppressed by partial inhibition of the gp130-Jak-Stat3 pathway without affecting Stat1. Fig. S5. Stimulation of gp130-Jak-Stat3 signaling does not affect aberrant Wnt–β-catenin signaling in the SW480 human CRC cell line.